The grant will allow Brinton to continue research to reveal the transformations in the brain that occur during female midlife aging that lead to greater risk of Alzheimer\u2019s disease.<\/p>\n
\u201cOur research has shown that women are at greater risk for Alzheimer\u2019s disease not because they live longer than men, but because the disease can start earlier in women, at midlife during their menopausal transition,\u201d Brinton said. \u201cWith the continuation of this grant funding from the National Institutes on Aging, we will continue to advance mechanistic, clinical and population discovery science and translate these discoveries into a platform for precision medicine to prevent, delay and treat Alzheimer\u2019s disease.\u201d<\/p>\n
Brinton and her CIBS colleagues Fei Yin, PhD<\/strong>, Kathleen Rodgers, PhD<\/strong>, and Francesca Vitali, PhD<\/strong>, and Tian Wang, PhD<\/strong>, along with Lisa Mosconi, PhD, of the Weill Cornell Medical College,\u00a0are focused on the earliest events that can occur during female midlife aging that can increase risk for Alzheimer\u2019s disease in later life. The average age for diagnosis is in a person\u2019s 70s, so the researchers are focused on what is happening in the female brain during the 50s. The midlife aging transition of the menopause could be the trigger for the start of the prodromal phase of Alzheimer\u2019s.<\/p>\n Each year, approximately 1.5 million American women enter into perimenopause, a neuroendocrine transition state unique to females. As of 2020, there were 45 million women in the U.S. over the age of 55. Globally, there are 850 million women between the ages of 40 and 60.<\/p>\n Alzheimer\u2019s is the only disease among the top 10 causes of death in America that cannot be prevented, cured or slowed.<\/p>\n This award is the fourth five-year extension of the NIH-funded Program Project Grant. Prior funding has allowed Dr. Brinton and her team to develop an integrated program to investigate the molecular, cellular and systems biology of immune signaling in the brain that initiate and drive advancement of the disease. Through an innovative research model, Dr. Brinton is working to develop neuro-immune biomarkers specific to stages of brain aging and create a platform for precision therapeutics.<\/p>\n","protected":false},"excerpt":{"rendered":" The grant will allow Brinton to continue research to reveal the transformations in the brain that occur during female midlife aging that lead to greater risk of Alzheimer\u2019s disease. \u201cOur research has shown that women are at greater risk for Alzheimer\u2019s disease not because they live longer than men, but because the disease can start […]<\/p>\n","protected":false},"author":1,"featured_media":1435,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5],"tags":[],"uahs_theme":[],"class_list":["post-302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-update"],"acf":[],"yoast_head":"\n